A selective review of experimental studies in cervical carcinoma.
نویسنده
چکیده
With various human clinical, epidemiological, and ex perimental data together with basic carcinogenesis ex perimentation, a working hypothesis of the development of cervical cancer is presented. Initiation may involve a carcinogen (perhaps herpesvirus type 2) altering the sus ceptible metaplastic cervical cell that is active in adoles cence and during pregnancy. Promotion by factors per haps related to coitus or to the continued metaplastic process in a field of abnormally mitosing cells allows for selection of a clone of cells with the characteristics of un limited growth and invasion.
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ورودعنوان ژورنال:
- Cancer research
دوره 33 6 شماره
صفحات -
تاریخ انتشار 1973